Our expertise in
key therapeutic areas
Solid or hematological malignancies, signal inhibitors, biological and cellular therapeutics, or autologous and allogeneic transplantation.
Autoimmune and inflammatory disorders, immune deficiency, immunopharmacology and therapeutics, graft rejection and graft-vs-host disease.
Retinal disease and macular degeneration, diabetic retinopathy, retinal vein thrombosis, cataracts and anterior eye disease.
Degenerative brain disease and dementia, migraine, stroke, movement disorders, epilepsy, multiple sclerosis and neuroimmunology.
Psoriasis and rosacea, urticarial, dermatitis and eczema, DRESS syndrome, skin malignancy, cosmetic medicine.
Rheumatoid and inflammatory arthritis, degenerative disease and osteoarthritis, muscle and skeletal disorders, osteoporosis.
Diabetes, hyperlipidemia, obesity and metabolic syndrome, inherited disorders, diet and nutrition.
Atherosclerosis, heart failure, cardiomyopathy, hypertension, arrhythmia, peripheral vascular disease and thrombosis.
Asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary hypertension, influenza and pneumonia.
Viral, fungal and microbial diseases, hepatitis, pneumonia, urinary tract disorders, complex and chronic infections, septicemia.
Inflammatory bowel disease, irritable bowel syndrome, liver disease and steatosis, stomach and colon cancer.
Glomerulonephritis, diabetic nephropathy, cystic disease, renal anemia, renal metabolic disorders, dialysis and transplantation.
All the services you need from
study design to high-level publication
For study design:
Our expert trial design team works closely with each sponsor to develop efficient Phase 1 - Phase IV trials using predictive biomarkers and agile adaptive or surrogate trial models with flexible basket or umbrella designs enabling rapid addition of new cohorts and efficient patient selection through baseline selection or short run-in strategies.
Our experienced Medical Directors ensure continuous study supervision and liaison with sites and sponsors, supervise pharmacovigilance to detect safety signals and dose-limiting toxicities, provide authorization for subsequent dose cohorts, review medical coding and reporting, and all other medical services critical for a safe and successful study.
Expert project managers work closely with each sponsor to identify precise objectives, timelines and outcomes; support trial committees; track communications, timelines, milestones and operations; and ensure that studies are conducted on time, within budget, and in accordance with all relevant regulatory guidelines.
For study operation:
Syreon streamlines site management, drawing on our international networks of expert academic and community investigators to ensure rapid engagement, commitment and contracting, IRB approval, training and set-up, with continuous support to speed the learning curve, improve protocol adherence and data accuracy, and minimize time and costs.
Syreon offers flexible integration of all forms of data input via its sophisticated and 21CFR part 11 fully compliant EDC and ePRO systems. These provide database programming, direct single-point entry or automated upload, data processing and queries, coding, integration and in-stream analysis of complex multidimensional institutional data.
Select full, risk-based or centralized strategies supported by our advanced data sciences for your clinical monitoring to ensure efficient trial management and high data quality. Incorporate sophisticated data-driven strategies to identify site risks, performance failures, and potential trial hazards in advance to ensure optimal quality and safety at lowest cost.
For study analysis and reporting:
We provide complete statistical support for all trials from adaptive clinical trial design to project simulation, in-stream data visualization and modeling, interim and formal trial analysis, DSMB support, and presentation of results to regulatory agencies and other bodies with a full complement of pharmacokinetic, dynamic, genomic, clinical and economic analyses.
Syreon Research Institute conducts full health economic analysis, cost-effectiveness and cost-utility modeling, creation of value dossiers and strategic pricing presentation across a broad range of acute and chronic disease states. Draw on our health policy expertise to interpret the evidence needed for public health policy-decisions.
Our expert editorial team of senior medical writers provides all necessary study documents, clinical reports, conference presentations and manuscripts, coordinating rigorous review by investigators, and enabling the results of the research study to be presented and published quickly in high-profile scientific journals.